Healthcare Supplement

Diindolylmethane Powder

Product Name: Diindolylmethane Powder
Other Name: DIM Powder, 3,3'-Diindolylmethane
Specifications: 98%-99% Diindolylmethane
Appearance: White Powder
Source: Synthetic
CAS No: 1968-05-4
Test Method: HPLC
MOQ: 1KG
Delivery Time: Delivery within one day from warehouse
Sample: Free sample available
Production Capacity: 2000KG/month
Certs: GMP, ISO9001, ISO22000, HACCP, KOSHER, HALAL
Content: Natural, Non-additive, Non-GMO, Treat by Heat Only
Categories: Cosmetic Ingredients, Healthcare Supplement, Pharm Ingredients
Payment: Multiple terms acceptable like T/T, LC, DA
Company Advantage: Kintainutri® mainly focuses on the production of high content plant extracts and pharmaceutical intermediates all the year round
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product details

Diindolylmethane Powder Manufacturers

Kintainutri® is a leading manufacturer of high-quality, high-purity Diindolylmethane (DIM) powder. Produced in accordance with pharmaceutical-grade standards, our products utilize advanced synthesis and purification technologies to ensure a consistently high purity level of 98% to 99%. Our GMP-certified manufacturing processes guarantee exceptional bioactivity and reliability across key applications—including hormone-balancing nutritional supplements, acne-regulating beauty products, and pharmaceutical research focused on breast and prostate health, as well as detoxification mechanisms.

If you want to buy Diindolylmethane powder, please contact us directly!

What Is Diindolylmethane Powder?

Diindolylmethane (DIM) is a naturally occurring compound found in cruciferous vegetables—such as broccoli, Brussels sprouts, cabbage, and kale. DIM possesses potential anti-androgenic and anti-tumor activities. As a dimer of indole-3-carbinol, Diindolylmethane Powder promotes beneficial estrogen metabolism in both sexes by lowering the levels of 16-hydroxy estrogen metabolites while increasing the production of 2-hydroxy estrogen metabolites, thereby enhancing antioxidant activity. Furthermore, it is believed to possess potential biological properties related to anti-cancer mechanisms and can be utilized as a dietary supplement.

Active Ingredient	Diindolylmethane	CAS number	1968-05-4
Molecular formula	_C17H14N2	Molecular Weight	246.31
Melting Point	167℃	Boiling Point	230℃
Density	_C17H14N21.271+0.06g/cm3(Predicted)	Specification	1kg, 25kg

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Diindolylmethane powder Production Process

Raw Material Pretreatment: Indole and formaldehyde were purified via vacuum distillation, and a 1–2% dilute hydrochloric acid solution was prepared to serve as the catalyst.

Catalytic condensation: Under conditions of 30–40°C, indole reacts with formaldehyde for 2–3 hours to yield crude DIM.

Neutralization and extraction: Adjust the pH to neutral to terminate the reaction, then extract and isolate the crude DIM using ethyl acetate.

Crystallization and Purification: Recover the solvent via reduced-pressure distillation, dissolve the residue in ethanol, and induce crystallization by cooling; repeat this process 1–2 times to enhance purity.

Vacuum Drying: Dry under vacuum at 50–60°C for 2 hours to remove residual solvent, yielding the final product. Unreacted indole is recovered and recycled.

Diindolylmethane powder Production Process

Diindolylmethane powder Benefits

Diindolylmethane benefits for women

Human papillomavirus (HPV) infection is a key factor driving the development of cervical lesions and their eventual progression to cancer. A clinical study involving women of childbearing age demonstrated that 3,3'-Diindolylmethane powder effectively promotes the regression of cervical intraepithelial neoplasia (CIN)—helping to clear lesions associated with HPV infection—while exhibiting an excellent safety profile.

Its mechanism of action involves modulating estrogen metabolism, inducing apoptosis in lesional cells, and restoring tumor suppressor gene activity, thereby significantly slowing, halting, or even reversing the process of neoplastic transformation within the cervical epithelium. Unlike invasive interventions such as surgery, our Diindolylmethane dim powder product offers a non-traumatic, cost-effective, and safe conservative treatment option—one particularly well-suited for young women planning for future childbearing—and holds clear clinical value within the field of gynecological health.

Diindolylmethane powder is a premium nutrient that supports women's breast health while regulating menstrual cycles and hormonal balance. It guides estrogen metabolism toward beneficial pathways, reducing the accumulation of harmful estrogen metabolites to promote the health of the breasts and uterus, thereby lowering the risk of hormone-related discomfort. Dim Powder helps alleviate symptoms of Premenstrual Syndrome (PMS)—such as abdominal bloating, breast tenderness, and mood swings—while stabilizing endocrine rhythms.

Its anti-inflammatory and antioxidant properties improve skin condition, reducing acne and dullness to brighten the complexion. Furthermore, 3,3'-Diindolylmethane aids in regulating metabolism and managing body fat to help maintain a lean physique, while also enhancing immune homeostasis and alleviating chronic inflammation. Long-term supplementation safeguards female reproductive health and boosts overall radiance and vitality, making it an ideal choice for women prioritizing hormonal balance, menstrual comfort, and skin health.

Diindolylmethane benefits for men

DIM helps men balance their internal hormone levels, thereby supporting prostate health and maintaining overall daily stability. It optimizes estrogen metabolism—reducing the accumulation of adverse estrogen metabolites—and lowers the risk of prostate-related discomfort while safeguarding the health of the urinary and reproductive systems. By activating the aryl hydrocarbon receptor pathway, DIM powder modulates immune and inflammatory responses, this helps alleviate issues associated with chronic inflammation and enhances the body's natural anti-inflammatory and antioxidant capabilities.

Furthermore, it aids in improving metabolic function, maintaining a healthy body weight, and boosting physical stamina and energy levels. By helping to alleviate fatigue, it enables men to remain in peak condition during both work and exercise. Suitable for adult men concerned with prostate health, hormonal balance, and daily physical vitality, long-term supplementation with DIM contributes to the maintenance of overall well-being.

Diindolylmethane for weight loss

Diindolylmethane (DIM), derived from cruciferous vegetables, is recognized in nutritional biochemistry research for its potential value in weight management. Its primary mechanism involves inhibiting adipogenesis, specifically, it reduces the differentiation of pre-adipocytes into mature adipocytes by modulating the activity of the USP2 enzyme, thereby curbing fat accumulation at its source. Concurrently, DIM regulates lipid metabolism and inhibits processes associated with fat synthesis, thereby aiding in the maintenance of metabolic equilibrium.

Furthermore, in high-fat diet models, DIM has demonstrated efficacy in ameliorating metabolic disorders and improving adipose tissue function. Kintainutri® offers standardized Diindolylmethane powder with a purity specification of 98%–99%, characterized by batch-to-batch consistency and suitability for use in the development of weight management formulations.

The protective responses of I3C and DIM on various diseases

source: https://pmc.ncbi.nlm.nih.gov/articles/PMC11902694/

In addition to these benefits, 3,3'-Diindolylmethane powder offers further advantages: it helps balance estrogen and androgen levels within the body, alleviates hair loss caused by hormonal imbalances, strengthens hair roots, and reduces shedding. Furthermore, it promotes a healthy oral environment by inhibiting harmful bacteria and reducing gum inflammation, thereby safeguarding gum health.

What Is Diindolylmethane Powder Used For?

Diindolylmethane supplement

DIM is a widely used dietary supplement that has demonstrated potent cancer chemopreventive effects in preclinical models. Clinical trials have shown promising results, particularly in the contexts of estrogen receptor (ER)-responsive breast cancer and androgen receptor-dependent prostate cancer. It optimizes estrogen metabolism, helping to alleviate premenstrual discomfort, menstrual fluctuations, and menopausal hot flashes in women, while assisting men in maintaining healthy hormone levels and boosting energy and vitality. Long-term supplementation aids in regulating endocrine balance, providing comprehensive health support for both men and women, making it an excellent choice for maintaining daily wellness.

Diindolylmethane cream

In the field of cosmetics, Diindolylmethane (DIM) regulates sebum secretion and combats inflammatory skin aging; it aids in modulating local hormone metabolism, specifically targeting hormonal acne and issues of excessive sebum production to reduce recurrent breakouts and improve rough, oily skin textures. Furthermore, leveraging its anti-inflammatory and soothing properties, it alleviates redness, sensitivity, and inflammation, while assisting in fading acne marks and hyperpigmentation. Formulated specifically for topical application, Diindolylmethane cream exerts its multifaceted effects through gentle skin absorption, offering a natural stabilizing solution that helps foster a healthy, clear, and balanced complexion.

Diindolylmethane powder dosage

How to take：

Industry	Typical Concentration	Key Applications	Form Examples
Nutraceuticals	50–200 mg/day	Estrogen balance, PCOS, hormonal acne	Capsules, gummies, powders
Cosmeceuticals	0.5–2% topical	Acne serums, anti-aging creams	Serums, moisturizers
Research	10–500 μM	Cell studies, oncoprotective mechanisms	In vitro assays, trial materials

Critical Footnotes

• Oral Safety Threshold :

Max 300 mg/day for adults (clinical studies show safety ≤200 mg long-term)

• Purity Requirement :

Use ≥98% purity DIM (avoid solvent residues)

• Bioavailability Boosters :

Combine with piperine (5–10 mg) or healthy fats for absorption, Based on 2023 clinical guidelines (J. Nutr. Biochem.) & industry formulation standards

Safety of Diindolylmethane powder

Skin Sensitivity & Allergies

Diindolylmethane powder is usually safe for topical use. However, if you have a history of sensitivities to supplements or related compounds, it’s wise to do a small patch test on your skin before using products containing it, like creams or serums. Stop use immediately if irritation occurs.

Safety & Toxicity Research

General Safety Limit : While no specific upper limit is set, moderate consumption (≤500 mg/day) is recommended for adults to avoid potential risks.

Acute Toxicity : Studies show no severe toxicity concerns at normal doses, but excessive intake may cause digestive discomfort.

Production Purity : Manufactured through strict extraction processes, ensuring ≥98% purity verified by HPLC, minimizing impurities.

International Compliance

• EU Cosmetic Regulation : Approved for topical use when meeting purity standards.

• FDA : Recognized as cosmetic ingredient (oral use requires separate approval).

• Asia : Compliant with China, Japan, and Korea cosmetic ingredient lists.

Where Can i Buy Diindolylmethane?

Kintainutri® promise that our raw materials are naturally grown without any additives.We have strict quality control and certification, High Purity Diindolylmethane powder ≥ 98% HPLC purity, Kosher, Halal and SGS compliant. Fully traceable to non-GMO soybean source. And we have strict batch testing for heavy metals, solvents and microbial contaminants.

We provide customized extraction solutions to produce Diindolylmethane powder in various specifications tailored to your requirements.We have reliable global supply chain, stable production capacity and competitive price. Bulk demand can be met.Our production facilities hold internationally recognized certifications including GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL, guaranteeing the highest standards for your peace of mind.

*KINTAI Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO

Reference:
[1]: https://en.wikipedia.org/wiki/3,3%27-Diindolylmethane
[2]: https://www.cancer.gov/publications/dictionaries/cancer-drug/def/diindolylmethane
[3]: https://pubmed.ncbi.nlm.nih.gov/18712169/
[4]: https://pmc.ncbi.nlm.nih.gov/articles/PMC4685602/

FAQ

We are manufacturer.
What does diindolylmethane powder do for women?

The health benefits of Diindolylmethane powder (DIM) for women primarily manifest in two areas: the regulation of estrogen metabolism and the support of cervical health. DIM facilitates the conversion of estrogen toward the more favorable metabolic pathway of 2-hydroxyestrone, thereby helping to maintain hormonal balance within the body and alleviate symptoms associated with estrogen dominance—such as premenstrual syndrome (PMS) and breast tenderness. Regarding cervical health, clinical studies have demonstrated that DIM can induce apoptosis in HPV-infected cells, showing promise as an adjunctive aid in the management of Cervical Intraepithelial Neoplasia (CIN). A daily dosage of 200–300 mg of DIM is generally well-tolerated; however, pregnant women, breastfeeding mothers, and individuals currently undergoing hormone therapy should consult a physician prior to use.
What does diindolylmethane powder do for men?

Diindolylmethane powder offers men two key health advantages: it helps maintain healthy hormone levels and supports prostate well-being. By modulating estrogen metabolism, DIM facilitates the conversion of potent estrogens into milder, more beneficial metabolites; simultaneously, it inhibits aromatase activity, thereby reducing the conversion of testosterone into estradiol. This dual mechanism helps maintain a healthy ratio of testosterone to estrogen within the male body, offering positive implications for alleviating symptoms associated with estrogen dominance.
Does diindolylmethane powder lower testosterone?

At standard supplemental doses, DIM powder does not lower testosterone levels, rather,It helps maintain healthy testosterone levels while supporting the activity of free testosterone.
Can diindolylmethane powder cause weight gain?

No, at normal dosages, DIM does not cause weight gain， on the contrary, it aids in weight management and metabolic balance. By regulating estrogen metabolism, improving the body's inflammatory state, and supporting fat metabolism, DIM helps control weight rather than causing weight gain. It helps inhibit fat cell differentiation and reduce fat accumulation, while alleviating water retention, bloating, and slowed metabolism associated with hormonal imbalances.
Is diindolylmethane powder safe?

Yes, diindolylmethane powder is generally safe for daily use when taken at recommended doses. It is a naturally derived, well-studied compound with a strong safety profile for long-term hormone balance and immune support.

Shipping & Packaging

● Packaging: Inside food grade bag, outer aluminum foil bag.

25kg use double-layer plastic container/fiber drum.

Or your choice.

● OEM Service Available: Customized packaging available, click here to know more.

● Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA

● American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.

● Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.

Please contact us and we will guide you with an easy and professional way for your order.

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